Published Papers

2020

Thymosin beta 4 is essential for adherens junction stability and epidermal planar cell polarity

Krishnanand Padmanabhan, Hanna Grobe, Jonathan Cohen, Arad Soffer, Adnan Mahali, Orit
Adir,
Ronen Zaidel-Bar, and Chen Luxenburg. Development 2020, In press.

Mechanosensing in embryogenesis

Agarwal P, Zaidel-Bar R. Curr Opin Cell Biol. 2020 Sep 5;68:1-9.

2019

Diverse roles of non-muscle myosin II contractility
in 3D cell migration

Agarwal P, Zaidel-Bar R. Essays Biochem. 2019 Oct 31;63(5):497-508.

Germ Granules Govern Small RNA Inheritance

Lev I, Toker IA, Mor Y, Nitzan A, Weintraub G, Antonova O, Bhonkar O, Ben Shushan I,
Seroussi U, Claycomb JM, Anava S, Gingold H, 
Zaidel-Bar R, Rechavi O. Curr Biol. 2019 Sep
9;29(17):2880-2891.

Reciprocal regulation of actomyosin organization and contractility in nonmuscle cells by tropomyosins and alpha-actinins

Hu S, Grobe H, Guo Z, Wang YH, Doss BL, Pan M, Ladoux B, Bershadsky AD, Zaidel-Bar R. (2019) Molecular Biology of the Cell. Jul 22;30(16):2025-2036.

Salmonella biofilms program innate immunity for persistence in Caenorhabditis elegans

Desai SK, Padmanabhan A, Harshe S, Zaidel-Bar R, Kenney LJ. (2019 ) Proc Natl Acad Sci U S A. Jun 18;116(25):12462-12467.

From cell shape to cell fate via the cytoskeleton - Insights from the epidermis

Luxenburg C, Zaidel-Bar R. (2019) Exp Cell Res. May 15;378(2):232-237.

The RhoGAP SPV-1 regulates calcium signaling to control the contractility of the Caenorhabditis elegans spermatheca during embryo transits

Bouffard J, Cecchetelli AD, Clifford C, Sethi K, Zaidel-Bar R, Cram EJ. (2019 ) Mol Biol Cell. Mar 21;30(7):907-922.

2018

Principles of Actomyosin Regulation In Vivo

Agarwal P, Zaidel-Bar R.  (2018) Trends Cell Biol. Oct 29. pii: S0962-8924(18)30161-2.

Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset

Priti A, Ong H-T, Toyama Y, Padmanabhan A, Dasgupta S, Krajnc M, Zaidel-Bar R. (2018) Nature Communications DOI: 10.1038/s41467-018-07149-2

The myosin light-chain kinase MLCK-1 relocalizes during Caenorhabditis elegans ovulation to promote actomyosin bundle assembly and drive contraction

Kelly CA, Wirshing ACE, Zaidel-Bar R, Cram EJ. (2018) Molecular Biology of the Cell 29(16):1975-1991

Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility

Chen Z, Oh D, Biswas KH, Yu CH, Zaidel-Bar R*, Groves JT. (2018) Proc Natl Acad Sci U S A. 115(25):E5696-E5705. *corresponding author

2017

Stretch-induced actomyosin contraction in epithelial tubes: Mechanotransduction pathways for tubular homeostasis

Sethi K, Cram EJ, Zaidel-Bar R. (2017) Semin Cell Dev Biol. pii: S1084-9521(17)30176-3.

Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis

Ding W-Y, Ong H-T, Hara Y, Wongsantichon J, Toyama Y, Robinson R, Nédélec F, Zaidel-Bar R. (2017) Journal of Cell Biology 216(5): 1371-1386.

Early events in the assembly of E-cadherin adhesions

Biswas KH, Zaidel-Bar R. (2017) Experimental Cell Research Feb 22. pii: S0014-4827(17)30090-3.

Long range self-organization of cytoskeletal myosin-II filament stacks

Hu S, Dasbiswas K, Guo Z, Tee Y-H, Thiagarajan V, Hersen P, Chew T-L, Safran SA, Zaidel-Bar R* and Bershadsky AD (2017) Nature Cell Biology 19(2):133-141. *corresponding author

Nanoscale architecture of cadherin-based adhesions

Bertocchi C, Wang Y, Ravasio A, Hara Y, Wu Y, Sailov T, Baird MA, Davidson MW, Zaidel-Bar R, Toyama Y, Ladoux B, Mege RM, and Kanchanawong P. (2017) Nature Cell Biology 19(1):28-37.

Non-junctional E-Cadherin Clusters Regulate the Actomyosin Cortex in the C. elegans Zygote

Padmanabhan A, Ong H-T and Zaidel-Bar R. (2017) Current Biology 27:1-10.

2016

Formin-mediated actin polymerization at cell-cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair

Vaman Rao M and Zaidel-Bar R. (2016) Molecular Biology of the Cell 27(18):2844-56.

Sustained α-catenin conformational activation at E-cadherin junctions in the absence of mechanical force

Biswas KH, Hartman KL, Zaidel-Bar R* and Groves JT*. (2016) Biophysical Journal 111(5):1044-52. 

*corresponding author

The AP-2 transcription factor APTF-2 is required for neuroblast and epidermal morphogenesis in Caenorhabditis elegans embryogenesis

Budirahardja Y, Tan PY, Doan T, Weisdepp P, Zaidel-Bar R. (2016) PLoS Genetics 12(5):e1006048.

2015

E-cadherin junction formation involves an active kinetic nucleation process

Biswas KH, Hartman KL, Yu C-H, Harrison OJ, Song H, Smith AW, Huang WYC, Lin W-C, Guo Z, Padmanabhan A, Troyanovsky SM, Dustin ML, Shapiro L, Honig B, Zaidel-Bar R and Groves JT. (2015) PNAS 112(35):10932-7.    

There are four dynamically and functionally distinct populations of E-cadherin in cell junctions

Erami Z, Anannya O, Schwarz JP, Timpson P, Yao W, Zaidel-Bar R, and Anderson KI. (2015) Biology Open 4(11):1481-9.

Structured illumination microscopy reveals focal adhesions are composed of linear subunits

Hu S, Tee YH, Kabla A, Zaidel-Bar R, Bershadsky A, Hersen P. (2015) Cytoskeleton (Hoboken) 72(5):235-45.

Glycosyl phosphatidylinositol anchor biosynthesis is essential for maintaining epithelial integrity during Caenorhabditis elegans embryogenesis

Budirahardja Y, Doan T, and Zaidel-Bar R. (2015) Plos Genetics 11(3):e1005082.

Jack of all trades: functional modularity in adherens junctions

Padmanabhan A, Vaman Rao M, Yao W, and Zaidel-Bar R. (2015) Current Opinions in Cell Biology 36:32-40.

The contractome - a systems view of actomyosin contractility in non-muscle cells

Zaidel-Bar R, Gou Z, and Luxenburg C. (2015) Journal of Cell Science 128(12):2209-17.

Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions

Wu Y, Kanchanawong P, and Zaidel-Bar R. (2015) Developmental Cell 32(2):139-54.

Transient membrane localization of SPV-1 drives cyclical actomyosin contractions in the C. elegans spermatheca

Tan P-Y and Zaidel-Bar R. (2015) Current Biology 25(2):141-51.

2014

E-cadherin adhesome complexity and robustness resolved by quantitative proteomics

Guo Z, Neilson LJ, Hang Z, Murray P, Zanivan S, and Zaidel-Bar R. (2014) Science Signaling 7(354), rs7.

Premetazoan origins and evolution of the cadherin adhesome

Murray P, and Zaidel-Bar R. (2014) Biology Open 3:1183-1195.

2013 and before

Cadherin adhesome components and interactions at a glance

Zaidel-Bar R. (2013) Journal of Cell Science 126:373-378.

A novel tool for the activation of endogenous diaphanous-related formins by light reveals thickening of stress fibers without an apparent increase in tension

Vaman Rao M. Chu P-H, Hahn KM, and Zaidel-Bar R (2013) Cytoskeleton (Hoboken) 70(7):394-407.

Regulation of Adherens Junction Dynamics by Phosphorylation Switches

Bertocchi C, Vaman Rao M, and Zaidel-Bar R. (2012) Journal of Signal Transduction, vol. 2012, Article ID 125295.

Tropomodulin Protects a-catenin-dependent Junctional-Actin Networks Under Stress during Epithelial Morphogenesis

Cox-Paulson EA, Walck-ShannonE, Lynch AM, Yamashiro S, Zaidel-Bar R, Eno CC, Ono S, Hardin J. (2012) Current Biology 21;22(16):1500-5.

Opening the floodgates: proteomics and the integrin adhesome

Geiger T, Zaidel-Bar R. (2012) Current Opinions in Cell Biology 24(5):562-8.

Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans

Neukomm LJ, Frei AP, Cabello J, Kinchen JM, Zaidel-Bar R, Ma Z, Haney LB, Hardin J, Ravichandran KS, Moreno S, Hengartner MO. (2011) Nature Cell Biology 13(1):79-86.

The switchable integrin adhesome

Zaidel-Bar R, Geiger B. (2010) Journal of Cell Science 123(9):1385-8.

The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis

Zaidel-Bar R, Joyce MJ, Lynch AM, Witte K, Audhya A, Hardin JD. (2010) Journal of Cell Biology 191(4):761-9.

Molting-specific downregulation of C. elegans body-wall muscle attachment sites: The role of RNF-5 E3 ligase

Zaidel-Bar R, Miller S, Broday L. (2010) Biochemical Biophysical Research Comm. 14;395(4):509-14.

Evolution of Complexity in the Integrin Adhesome

Zaidel-Bar R.  (2009) Journal of Cell Biology 186(3):317-21.

Temporal evolution of cell focal adhesions: experimental observations and shear stress profiles

Aroush DRB, Zaidel-Bar R, Bershadsky AD, Wagner HD. (2008) Soft Matter 4 (12):2410-2417

The C. elegans Zonula Occludens ortholog ZOO-1 cooperates with the cadherin-catenin complex to recruit actin during epidermal morphogenesis

Lockwood C, Zaidel-Bar R, Hardin JD. (2008) Current Biology 18(17):1333-7.

Functional atlas of the integrin adhesome

Zaidel-Bar R, Itzkovitz S, Ma’ayan A, Iyengar R, Geiger B. (2007) Nature Cell Biology 9(8):858-67.

A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions

Zaidel-Bar R, Milo R, Kam Z, Geiger B. (2007) Journal of Cell Science 120(Pt1):137-48.

Polarized down-regulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow

Zaidel-Bar R, Kam Z, Geiger B. (2005) Journal of Cell Science 118(Pt17):3997-4007.

Hierarchical assembly of cell-matrix adhesion complexes

Zaidel-Bar R, Cohen M, Addadi L, Geiger B. (2004) Biochemical Society Transactions 32(Pt3):416-20.

Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells

Zaidel-Bar R, Ballestrem C, Kam Z, Geiger B. (2003) Journal of Cell Science 116(Pt22):4605-13.